Frontiers in Microbiology (Jan 2023)
Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort
- Zhaofeng Chen,
- Zhaofeng Chen,
- Ya Zheng,
- Ya Zheng,
- Ping Fan,
- Min Li,
- Wei Liu,
- Hao Yuan,
- Hao Yuan,
- Xin Liu,
- Zhiyi Zhang,
- Zhengqi Wu,
- Yuping Wang,
- Yuping Wang,
- Rui Ji,
- Rui Ji,
- Qinghong Guo,
- Qinghong Guo,
- Yuwei Ye,
- Yuwei Ye,
- Jinhua Zhang,
- Xiaohua Li,
- Feng An,
- Linzhi Lu,
- Youpeng Li,
- Xiang Wang,
- Jun Zhang,
- Jun Zhang,
- Quanlin Guan,
- Qiang Li,
- Qiang Li,
- Min Liu,
- Min Liu,
- Qian Ren,
- Qian Ren,
- Xiaobin Hu,
- Hong Lu,
- Hong Lu,
- Hongling Zhang,
- Hongling Zhang,
- Yue Zhao,
- Yue Zhao,
- Xi Gou,
- Xi Gou,
- Xiaochuang Shu,
- Xiaochuang Shu,
- Jun Wang,
- Jun Wang,
- Zenan Hu,
- Zenan Hu,
- Siqian Xue,
- Jiankang Liu,
- Yongning Zhou,
- Yongning Zhou
Affiliations
- Zhaofeng Chen
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Zhaofeng Chen
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Ya Zheng
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Ya Zheng
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Ping Fan
- Gansu Wuwei Tumor Hospital, Wuwei, Gansu, China
- Min Li
- School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China
- Wei Liu
- School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China
- Hao Yuan
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Hao Yuan
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Xin Liu
- Department of Gastroenterology, The 940th Hospital of Joint Service Logistics Support Force of Chinese People's Liberation Army, Lanzhou, Gansu, China
- Zhiyi Zhang
- Gansu Wuwei Tumor Hospital, Wuwei, Gansu, China
- Zhengqi Wu
- Gansu Wuwei Tumor Hospital, Wuwei, Gansu, China
- Yuping Wang
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Yuping Wang
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Rui Ji
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Rui Ji
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Qinghong Guo
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Qinghong Guo
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Yuwei Ye
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Yuwei Ye
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Jinhua Zhang
- Gansu Second Provincial People’s Hospital, Lanzhou, Gansu, China
- Xiaohua Li
- Wuwei Liangzhou Hospital, Wuwei, Gansu, China
- Feng An
- Wuwei People's Hospital, Wuwei, Gansu, China
- Linzhi Lu
- Gansu Wuwei Tumor Hospital, Wuwei, Gansu, China
- Youpeng Li
- Minqin People's Hospital, Minqin, Gansu, China
- Xiang Wang
- 0Lanzhou University Second Hospital, Lanzhou, Gansu, China
- Jun Zhang
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Jun Zhang
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Quanlin Guan
- 1Surgical Oncology Department, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Qiang Li
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Qiang Li
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Min Liu
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Min Liu
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Qian Ren
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Qian Ren
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Xiaobin Hu
- 2School of Public Health, Lanzhou University, Lanzhou, Gansu, China
- Hong Lu
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Hong Lu
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Hongling Zhang
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Hongling Zhang
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Yue Zhao
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Yue Zhao
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Xi Gou
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Xi Gou
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Xiaochuang Shu
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Xiaochuang Shu
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Jun Wang
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Jun Wang
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Zenan Hu
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Zenan Hu
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Siqian Xue
- 3Interventional Radiology Department, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Jiankang Liu
- 4Harvard Medical School, Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA, United States
- Yongning Zhou
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Yongning Zhou
- Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- DOI
- https://doi.org/10.3389/fmicb.2022.1024155
- Journal volume & issue
-
Vol. 13
Abstract
Several risk factors have been identified for the development of gastric adenocarcinoma (GAC), where the control group was usually a healthy population. However, it is unclear at what stage known risk factor exert their influence toward the progression to cancer. Based on the Wuwei Cohort, we enrolled 1,739 patients with chronic non-atrophic gastritis (no-CAG), 3,409 patients with chronic atrophic gastritis (CAG), 1,757 patients with intestinal metaplasia (IM), 2,239 patients with low-grade dysplasia (LGD), and 182 patients with high-grade dysplasia (HGD) or GAC to assess the risk factors between each two consecutive stages from no-CAG to GAC/HGD using adjusted logistic regression. We found that different groups of risk factors were associated with different stages. Age, occupation of farmer, low annual family income, Helicobacter pylori (H. pylori) infection, drinking, eating hot food, histories of gastritis and peptic ulcer were associated with the development of CAG. Age, illiteracy, H. pylori infection, smoking, eating hot food, eating quickly, and histories of gastritis and gallbladder diseases were associated with the progression to IM from CAG. Male, occupation of farmer and history of peptic ulcer were associated with the development of LGD from IM. Age, male and polyp history appeared to be risk factors associated with the development of GAC/HGD from LGD. In conclusion, it seems that most risk factors function more as a set of switches that initiated the GAC carcinogenesis. H. Pylori eradication and control of other risk factors should be conducted before IM to decrease the incidence of GAC.
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