Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1

• David J. Huggins,
• Bryn S. Hardwick,
• Pooja Sharma,
• Amy Emery,
• Luca Laraia,
• Fengzhi Zhang,
• Ana J. Narvaez,
• Meredith Roberts-Thomson,
• Alex T. Crooks,
• Robert G. Boyle,
• Richard Boyce,
• David W. Walker,
• Natalia Mateu,
• Grahame J. McKenzie,
• David R. Spring,
• Ashok R. Venkitaraman

Affiliations

David J. Huggins

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom

Bryn S. Hardwick

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom

Pooja Sharma

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom

Amy Emery

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom

Luca Laraia

Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Fengzhi Zhang

Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Ana J. Narvaez

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom

Meredith Roberts-Thomson

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom

Alex T. Crooks

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom

Robert G. Boyle

Sentinel Oncology Ltd., Cambridge, United Kingdom

Richard Boyce

Sentinel Oncology Ltd., Cambridge, United Kingdom

David W. Walker

Sentinel Oncology Ltd., Cambridge, United Kingdom

Natalia Mateu

Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Grahame J. McKenzie

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom

David R. Spring

Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Ashok R. Venkitaraman

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom