Nature Communications (Jan 2020)

Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion across biological membranes

  • Manish Debnath,
  • Sandipan Chakraborty,
  • Y. Pavan Kumar,
  • Ritapa Chaudhuri,
  • Biman Jana,
  • Jyotirmayee Dash

DOI
https://doi.org/10.1038/s41467-019-13834-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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DNA based ionophores can mediate efficient ion transport and are crucial to understand the biological role of their natural counterparts. Here authors engineer a telomeric DNA G-quadruplex based ionophore which transports K+ in a stimuli responsive manner.