Nature Communications (Mar 2018)

Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor

  • Keita Sato,
  • Takahiro Yamashita,
  • Hideyo Ohuchi,
  • Atsuko Takeuchi,
  • Hitoshi Gotoh,
  • Katsuhiko Ono,
  • Misao Mizuno,
  • Yasuhisa Mizutani,
  • Sayuri Tomonari,
  • Kazumi Sakai,
  • Yasushi Imamoto,
  • Akimori Wada,
  • Yoshinori Shichida

DOI
https://doi.org/10.1038/s41467-018-03603-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Opsins are G protein-coupled receptors which are activated by light-triggered retinal 11-cis-to-all-trans photoisomerization. Here, the authors report a vertebrate non-visual opsin (Opn5L1) that functions as a Gi-coupled retinal receptor, is deactivated by light and can thermally self-regenerate.