Shape-controlled MnO nanoparticles as T1 MRI contrast agents
A. Banerjee,
W. Zeng,
M. Taheri,
B. Blasiak,
B. Tomanek,
S. Trudel
Affiliations
A. Banerjee
Department of Chemistry and Institute for Quantum Science and Technology, University of Calgary, 2500 University Dr. NW, Calgary, Alberta T2N 1N4, Canada
W. Zeng
Department of Chemistry and Institute for Quantum Science and Technology, University of Calgary, 2500 University Dr. NW, Calgary, Alberta T2N 1N4, Canada
M. Taheri
Department of Chemistry and Institute for Quantum Science and Technology, University of Calgary, 2500 University Dr. NW, Calgary, Alberta T2N 1N4, Canada
B. Blasiak
Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada and Institute of Nuclear Physics, Polish Academy of Sciences, 152 Radzikowskiego, Krakow 31-342, Poland
B. Tomanek
Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada and Institute of Nuclear Physics, Polish Academy of Sciences, 152 Radzikowskiego, Krakow 31-342, Poland
S. Trudel
Department of Chemistry and Institute for Quantum Science and Technology, University of Calgary, 2500 University Dr. NW, Calgary, Alberta T2N 1N4, Canada
Magnetic resonance imaging is a non-invasive imaging method that offers high-resolution, high quality in vivo visualization for medical diagnostics. Magnetic nanoparticles (NPs) containing Mn2+ offer an attractive alternative to Gd-based molecular contrast agents for T1 MRI. In this work, we show that highly anisotropic MnO NPs can be generated from a single precursor using simple synthetic protocols. These anisotropic morphologies offer better contrast augmentation when compared to spherical MnO NPs of similar sizes.
