The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface

Shengyu Wu; Shengyu Wu; Han Xie; Yao Su; Yao Su; Xinrui Jia; Xinrui Jia; Yabing Mi; Yabing Mi; Yuanhui Jia; Hao Ying

doi:10.3389/fendo.2023.1205408

Frontiers in Endocrinology (Aug 2023)

The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface

Shengyu Wu,
Shengyu Wu,
Han Xie,
Yao Su,
Yao Su,
Xinrui Jia,
Xinrui Jia,
Yabing Mi,
Yabing Mi,
Yuanhui Jia,
Hao Ying

Affiliations

Shengyu Wu: Department of Clinical Medicine, Tongji University School of Medicine, Shanghai, China
Shengyu Wu: Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
Han Xie: Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
Yao Su: Department of Clinical Medicine, Tongji University School of Medicine, Shanghai, China
Yao Su: Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
Xinrui Jia: Department of Clinical Medicine, Tongji University School of Medicine, Shanghai, China
Xinrui Jia: Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
Yabing Mi: Department of Clinical Medicine, Tongji University School of Medicine, Shanghai, China
Yabing Mi: Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
Yuanhui Jia: Clinical and Translational Research Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
Hao Ying: Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China

DOI: https://doi.org/10.3389/fendo.2023.1205408
Journal volume & issue: Vol. 14

Abstract

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The maternal-fetal interface is defined as the interface between maternal tissue and sections of the fetus in close contact. RNA methylation modifications are the most frequent kind of RNA alterations. It is effective throughout both normal and pathological implantation and placentation during pregnancy. By influencing early embryo development, embryo implantation, endometrium receptivity, immune microenvironment, as well as some implantation and placentation-related disorders like miscarriage and preeclampsia, it is essential for the establishment of the maternal-fetal interface. Our review focuses on the role of dynamic RNA methylation at the maternal-fetal interface, which has received little attention thus far. It has given the mechanistic underpinnings for both normal and abnormal implantation and placentation and could eventually provide an entirely novel approach to treating related complications.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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Abstract

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