Evaluation on Stability of Plant-Based Softgels (SeaGel® Technology) versus Gelatine Softgels

Abstract

In this study, a simple model fill formulation of Ibuprofen was encapsulated using either gelatine as the shell-forming material or a plant-based material based on IFF’s SeaGel® technology (noted as SeaGel® softgels). The result indicates a similar performance at time zero between animal-sourced material (gelatine) and plant-based material (SeaGel®). Importantly, at accelerated conditions, SeaGel® showed no change in performance in disintegration and dissolution over 6 months of stability compared to gelatine which showed significantly slower disintegration and dissolution behaviour than freshly produced gelatine softgels. This work indicates the superior performance of gelatine alternative SeaGel® softgels during stability and long-term performance.

Keywords

• gelatine
• seagel®
• ibuprofen
• softgel capsules.