INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMA

Abstract

Studies were conducted using ascetic HA-1 hepatomas and ascitic Ehrlich’s carcinoma cells. After passage of cells in mice, cell culture containing tumor-associated macrophages was studied. It was shown that the very low-density lipoprotein (VLDL)-cortisol complex significantly inhibited proliferative activity of tumor cells. The obtained constant of cortisol binding to VLDL indicated that the protein component of lipoproteins participated in the complex formation. Tumor-associated macrophages were suggested to play an important role in the formation of this complex. It was found that inhibition of tumor cell growth was related to apoptosis.

Keywords

• tumor cells
• lipoproteins
• cortisol
• tumor-associated macrophages
• biosynthesis of nucleic acid