The effective dose of butorphanol tartrate in patients of different ages undergoing painless gastroscopy

Abstract

Objective This study evaluated the 50% effective dose (ED 50 ) and 95% effective dose (ED 95 ) of butorphanol tartrate in patients undergoing painless gastroscopy. Methods Patients who underwent painless gastroscopy at Binzhou Medical University Hospital were divided into the youth, middle-aged, and older groups. The ED 50 and ED 95 required for successful sedation using butorphanol tartrate were measured using the Dixon up-and-down method in patients in the different age groups. Patients in each group were administered intravenous butorphanol 5 minutes before gastroscopy. Each patient was administered 2 mg/kg propofol. The ED 50 and ED 95 of butorphanol were calculated using probit analysis. Results In total, 95 patients were included. The ED 50 s of butorphanol in the youth, middle-aged, and older groups were 7.384, 6.657, and 6.364 μg/kg, respectively. The ED 95 s of butorphanol doses in these groups were 9.108, 8.419, and 7.348 μg/kg, respectively. Conclusions The ED 50 and ED 95 varied among the age groups, indicating that the effective dose decreases with age.