Molecules
(Dec 2023)
An Operationally Simple Approach to Indole Derivatives from 2-Alkenylanilines Utilizing an Oxidation–Intramolecular Cyclization–Elimination Sequence
Lauren N. Hines,
Jacob R. King,
Alex C. Atwood,
Rachel M. Chapman,
Matthew B. Griffey,
Christine R. Tutwiler,
Christopher Jon Monceaux
Affiliations
Lauren N. Hines
Department of Chemistry, Radford University, Radford, VA 24142, USA
Jacob R. King
Department of Chemistry, Radford University, Radford, VA 24142, USA
Alex C. Atwood
Department of Chemistry, Radford University, Radford, VA 24142, USA
Rachel M. Chapman
Department of Chemistry, Radford University, Radford, VA 24142, USA
Matthew B. Griffey
Department of Chemistry, Radford University, Radford, VA 24142, USA
Christine R. Tutwiler
Department of Chemistry, Radford University, Radford, VA 24142, USA
Christopher Jon Monceaux
Department of Chemistry, Radford University, Radford, VA 24142, USA
DOI
https://doi.org/10.3390/molecules28247968
Journal volume & issue
Vol. 28,
no. 24
Abstract
Read online
Herein we describe a novel route to indole derivatives from a variety of N-substituted 2-alkenylanilines. This route features three operationally simple steps: (1) oxidation to convert N-substituted 2-alkenylanilines into epoxide intermediates, (2) intramolecular cyclization, and (3) the acid-catalyzed elimination of water.
Keywords
WeChat QR code
Close
