Nature Communications (Jun 2018)
Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth
- Yuhan Chen,
- Qingyang Huang,
- Wen Liu,
- Qiong Zhu,
- Chun-Ping Cui,
- Liang Xu,
- Xing Guo,
- Ping Wang,
- Jingwen Liu,
- Guanglong Dong,
- Wenyi Wei,
- Cui Hua Liu,
- Zhichun Feng,
- Fuchu He,
- Lingqiang Zhang
Affiliations
- Yuhan Chen
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Qingyang Huang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Wen Liu
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Qiong Zhu
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Chun-Ping Cui
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Liang Xu
- Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine
- Xing Guo
- Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine
- Ping Wang
- Department of Central Laboratory, Shanghai Tenth People’s Hospital, School of Life Science and Technology, Tongji University
- Jingwen Liu
- Department of General Surgery, Chinese People’s Liberation Army General Hospital
- Guanglong Dong
- Department of General Surgery, Chinese People’s Liberation Army General Hospital
- Wenyi Wei
- Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Cui Hua Liu
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Zhichun Feng
- Affiliated BaYi Children’s Hospital, PLA Army General Hospital, National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing Key Laboratory of Pediatric Organ Failure
- Fuchu He
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Lingqiang Zhang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
- DOI
- https://doi.org/10.1038/s41467-018-04815-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 21
Abstract
Changes in glucose metabolism can lead to tumor development, but the involvement of splicing factors is unclear. Here, the authors screened for SR proteins and identified SRSF5 stability is enhanced in response to glucose elevation to promote alternative splicing of CCAR1 which facilitates tumor growth.
