Cognitive screening test for rehabilitation using spatiotemporal data extracted from a digital trail making test part-A
Kouki Kubo,
Seiji Hama,
Akira Furui,
Tomohiko Mizuguchi,
Zu Soh,
Akiko Yanagawa,
Akihiko Kandori,
Hiroto Sakai,
Yutaro Morisako,
Yuki Orino,
Maho Hamai,
Kasumi Fujita,
Shigeto Yamawaki,
Toshio Tsuji
Affiliations
Kouki Kubo
Department of Rehabilitation, Hibino Hospital, Hiroshima, Hiroshima, Japan
Seiji Hama
Department of Rehabilitation, Hibino Hospital, Hiroshima, Hiroshima, Japan; Center for Brain, Mind and KANSEI Sciences Research, Hiroshima University, Hiroshima, Hiroshima, Japan; Corresponding author. Department of Rehabilitation, Hibino Hospital, Tomo-higashi 7-9-2, Asaminami-ku, Hiroshima, 731-3164, Japan.
Akira Furui
Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi-Hiroshima, Hiroshima, 739-8527, Japan
Tomohiko Mizuguchi
New Business Producing Division, Business Development Department, Maxell, Ltd., Tokyo, Japan
Zu Soh
Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi-Hiroshima, Hiroshima, 739-8527, Japan
Akiko Yanagawa
Department of Rehabilitation, Hibino Hospital, Hiroshima, Hiroshima, Japan
Akihiko Kandori
Center for Exploratory Research, Research and Development Group, Hitachi Ltd., Tokyo, Japan
Hiroto Sakai
Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi-Hiroshima, Hiroshima, 739-8527, Japan
Yutaro Morisako
Department of Rehabilitation, Hibino Hospital, Hiroshima, Hiroshima, Japan
Yuki Orino
Department of Rehabilitation, Hibino Hospital, Hiroshima, Hiroshima, Japan
Maho Hamai
Department of Rehabilitation, Hibino Hospital, Hiroshima, Hiroshima, Japan
Kasumi Fujita
Department of Rehabilitation, Hibino Hospital, Hiroshima, Hiroshima, Japan
Shigeto Yamawaki
Center for Brain, Mind and KANSEI Sciences Research, Hiroshima University, Hiroshima, Hiroshima, Japan
Toshio Tsuji
Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi-Hiroshima, Hiroshima, 739-8527, Japan; Corresponding author. Graduate School of Advanced Science and Engineering, Hiroshima University. Kagamiyama 1-4-1, Higashi-Hiroshima, 739-8527, Japan.
We investigated a newly developed digitized Trail Making Test using an iPad (iTMT) as a brief cognitive function screening test. We found that the iTMT part-A (iTMT-A) can estimate generalized cognitive function in rehabilitation inpatients examined using the Mini-Mental State Examination (MMSE). Forty-two hospitalized participants undergoing rehabilitation (rehab participants), 30 of whom had cerebral infarction/hemorrhage (stroke participants), performed the iTMT five times (first three times: iTMT-A; fourth: paper version of TMT-A; fifth: the inverse version of iTMT-A) and the MMSE once. Each iTMT-A trial's completion time was divided into the move and dwell times. A linear mixed model following post-hoc tests revealed that the completion time of the third and fourth iTMT-A was faster compared to that of the first iTMT-A, suggesting the presence of a learning effect. In the partial least squares (PLS) regression analysis, the coefficient of determination for estimating the MMSE score was increased by using the dwell and move times extracted from the repeated iTMT-A and the availability of TMT-B, even for subjects with low MMSE scores. These findings indicate that the dwell time of iTMT-A may be important for estimating cognitive function. The iTMT-A extracts significant factors temporally and spatially, and by incorporating the learning effect of repeated trials, it may be possible to screen cognitive and physical functions for rehabilitation patients.
