Nanoscale TiO2 nanotubes as a basis for governing cell behaviors and application challenges

Abstract

Min Li,1 Ying Yang2 1Department of Oncology, Changsha Central Hospital, Changsha, People’s Republic of China; 2Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, People’s Republic of ChinaTiO2 nanotube arrays with well-ordered nanotubular structures and controllable dimensions have emerged as a favorable substrate for advanced cell culturing with regulable cell behavior and differentiation.1,2 Unfortunately, the biological effects of nanotubes with different surface features on various cell lines are still inconsistent and inconclusive. Therefore, we read with great interest the enlightening work from Tian et al3 published in the International Journal of Nanomedicine on investigating the effects and molecular mechanisms of TiO2 nanotubes with various topographies and structures on the biological behavior of cultured cells.View the original paper by Tian and colleagues.

Keywords

• TiO2 nanotubes
• cell behaviors
• application challenges