Low-dose interleukin-2 as a novel therapeutic option for refractory paraneoplastic neurologic syndrome: a case of chronic relapsing anti-Ma2/Ta paraneoplastic myeloradiculopathy
Seon-Jae Ahn,
Han-Sang Lee,
Woo-Jin Lee,
Kon Chu
Affiliations
Seon-Jae Ahn
Center for Hospital Medicine, Seoul National University Hospital, Seoul, Korea
Han-Sang Lee
Center for Hospital Medicine, Seoul National University Hospital, Seoul, Korea
Woo-Jin Lee
Center for Hospital Medicine, Seoul National University Hospital, Seoul, Korea
Kon Chu
Department of Neurology, Comprehensive Epilepsy Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Paraneoplastic neurologic syndromes (PNS) caused by anti-Ma2/Ta antibodies have diverse presentations. Myeloradiculopathy is one anti-Ma2/Ta-associated PNS manifestation. We report the case of a patient with chronic relapsing anti-Ma2/Ta paraneoplastic myeloradiculopathy. The patient was successfully treated with low-dose human recombinant interleukin-2, despite having chronic relapsing symptoms and a refractory response to conventional immunotherapy.
