São Paulo Medical Journal ()

A t (9;11) translocation in childhood acute mixed leukemia

  • Maria de Lourdes Lopes Ferrari Chauffaille,
  • Mihoko Yamamoto,
  • Vicente Odone Filho,
  • Maria Thereza Almeida,
  • Paulo Maluf Jr.,
  • Lilian M. Cristofani,
  • José Kerbauy,
  • Suzana C. Raimondi

DOI
https://doi.org/10.1590/S1516-31801996000200004
Journal volume & issue
Vol. 114, no. 2
pp. 1127 – 1130

Abstract

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We present the case of a child with acute lymphoid leukemia (ALL) who was morphologically classified as FAB L1 (PAS and peroxidase were negative). Remission was achieved with an ALL-type protocol (GBTLI). Five months after the discontinuation of therapy, the patient presented mixed leukemia (CD10, CD19, CD13 and CD33 were positive) with t (9;11) (p21;q23) translocation. Unfortunately, as cytogenetic and immunophenotype studies were not performed at diagnosis, two possibilities could be considered for the relapse; secondary mixed leukemia with clonal chromosome changes, or mixed leukemia from the beginning.

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