Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract
Raluca Isac,
Diana-Georgiana Basaca,
Ioana-Cristina Olariu,
Ramona F. Stroescu,
Andrada-Mara Ardelean,
Ruxandra M. Steflea,
Mihai Gafencu,
Adela Chirita-Emandi,
Iulia Cristina Bagiu,
Florin George Horhat,
Dan-Dumitru Vulcanescu,
Dan Ionescu,
Gabriela Doros
Affiliations
Raluca Isac
IIIrd Pediatric Clinic, Department of Pediatrics, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 300041 Timișoara, Romania
Diana-Georgiana Basaca
Emergency Hospital for Children “Louis Turcanu”, 300011 Timișoara, Romania
Ioana-Cristina Olariu
IIIrd Pediatric Clinic, Department of Pediatrics, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 300041 Timișoara, Romania
Ramona F. Stroescu
Emergency Hospital for Children “Louis Turcanu”, 300011 Timișoara, Romania
Andrada-Mara Ardelean
IIIrd Pediatric Clinic, Department of Pediatrics, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 300041 Timișoara, Romania
Ruxandra M. Steflea
IIIrd Pediatric Clinic, Department of Pediatrics, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 300041 Timișoara, Romania
Mihai Gafencu
IIIrd Pediatric Clinic, Department of Pediatrics, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 300041 Timișoara, Romania
Adela Chirita-Emandi
Emergency Hospital for Children “Louis Turcanu”, 300011 Timișoara, Romania
Iulia Cristina Bagiu
Multidisciplinary Research Center on Antimicrobial Resistance (MULTI-REZ), Microbiology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timișoara, Romania
Florin George Horhat
Multidisciplinary Research Center on Antimicrobial Resistance (MULTI-REZ), Microbiology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timișoara, Romania
Dan-Dumitru Vulcanescu
Emergency Hospital for Children “Louis Turcanu”, 300011 Timișoara, Romania
Dan Ionescu
Physical Education and Sports Department, Polytechnic University, 300223 Timișoara, Romania
Gabriela Doros
IIIrd Pediatric Clinic, Department of Pediatrics, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 300041 Timișoara, Romania
Background: Urinary tract infections (UTI) are common in children worldwide. Congenital anomalies of kidney and urinary tract (CAKUT) increase the risk of UTI and consequently antibiotic resistance. Antibiotic resistance represents an important public health issue worldwide. We aimed to evaluate the local trend in terms of bacterial uropathogen resistance in the western part of Romania in children with CAKUT and UTI. Methods: 252 children with CAKUT were admitted to our hospital over a five-year period. Of them, 91 developed at least one UTI episode, with a total number of 260 positive urine cultures. We collected data about age at diagnosis of CAKUT, sex, origin environment, type and side of CAKUT, number of UTIs, type of uropathogen, and uropathogens antibiotic resistance. Results: Distribution of uropathogens was Escherichia coli (38.84%), Klebsiella spp. (21.15%), Enterococcus spp. (15.76%), Proteus spp. (8.07%), Pseudomonas spp. (8.07%), Enterobacter spp. (2.3%), other Gram-negative bacteria (2.3%), and other Gram-positive bacteria (3.45%). High antibiotic resistance was detected for ampicillin, amoxicillin, and second-generation cephalosporins. Escherichia coli presented high resistance for cefepime and ceftriaxone. Pseudomonas spp. remained susceptible to amikacin, quinolones, and colistin. Vancomycin, teicoplanin, linezolid, and piperacillin/tazobactam remained effective in treating Gram-positive UTI. Conclusions: High antibiotic resistance was identified for frequently used antibiotics. Lower antibiotic resistance was observed for some broad-spectrum antibiotics. Understanding uropathogens’ antibiotic resistance is important in creating treatment recommendations, based on international guidelines, local resistance patterns, and patient particularities.