Increased Gestational Weight Gain is Associated with a Higher Risk of Offspring Adiposity Before Five Years of Age: A Population-Based Cohort Study

Abstract

Shuang Zhang,1,2 Nan Li,1 Weiqin Li,1 Leishen Wang,1 Enqing Liu,1 Tao Zhang,1 Wei Dong,1 Jiujing Chen,2 Junhong Leng1 1Tianjin Women’s and Children’s Health Center, Tianjin, People’s Republic of China; 2NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, People’s Republic of ChinaCorrespondence: Junhong Leng, Email [email protected]: We aim to investigate the influence of weight gain during pregnancy on the risk of offspring adiposity before five years old.Methods: We retrospectively collected health information from the Tianjin mother-child cohort. Offspring outcome was BMI Z-score and prevalence of childhood adiposity from 0.5– 5 years old. Gestational weight gain was analyzed using continuous and categorical variables evaluated by the IOM guidelines. Multivariate analysis adjusted maternal age, prepregnancy BMI, maternal height, smoking, cesarean section, gestational age at birth, birth weight, birth length, and mode of infant feeding during 0– 6 months.Results: Gestational weight gain contributed to offspring’s BMI Z-score from 1– 5 years old, and the effect was most obvious in the first half of pregnancy (multivariate analysis, at 1, 2, 2.5, 3, 4, and 5 years of age: β 0.011, 95% CI 0.008– 0.014; β 0.017, 95% CI 0.015– 0.020; β 0.005, 95%CI 0.002-0.008; β 0.018, 95% CI 0.015– 0.021; β 0.014, 95% CI 0.009– 0.020; β 0.013, 95% CI 0.005– 0.021). Excessive weight gain was associated with a higher prevalence of offspring adiposity before five years, even if prepregnancy BMI is normal. Multivariate regression analysis further confirmed that excessive weight gain during the first half of pregnancy significantly increased the risk of childhood obesity at aged one and three (AOR 1.083, 95% CI 1.003– 1.169; AOR 1.158, 95% CI 1.036– 1.293).Conclusion: Offspring have a higher risk of preschool adiposity when gestational weight gain was excessive during the first half of pregnancy.Keywords: gestational weight gain, the first half of pregnancy, childhood obesity, retrospective cohort study

Keywords

• gestational weight gain
• the first half of pregnancy
• childhood obesity
• retrospective cohort study