Análise epidemiológica de pacientes com infecção latente tuberculosa atendidos em hospital pediátrico terciário de Florianópolis

Abstract

OBJECTIVE: Clinical and epidemiological analysis of pediatric patients with LTBI (latent tuberculosis infection). METHOD: Observational, descriptive, analytical and retrospective research, with data collection from medical records of patients suspected of having LTBI treated at a tertiary pediatric hospital in Florianópolis, Brazil from January 2011 to May 2020. RESULTS: 203 medical records were analyzed. A total of 112 patients confirmed to have LTBI. The main source case was the mother and household infection was predominant. The treatment time from the source case to the diagnosis in the child was less than 6 months in 87% of the cases. An investigation of the other source case contacts was realized in 60% of the cases. 84% received isoniazid and 15% received rifampicin. Two patients had adverse event to isoniazid. There was a monthly consultations frequency in 51% of cases. 50% of the patients finished the treatment. CONCLUSIONS: LTBI was found in more than half of the investigated patients, but the number could be even higher considering the frequent loss of follow-up regarding cases in the initial medical analysis. Approximately 10% had tuberculin conversion. Household transmission was the predominant one, and the main source case was the mother. The investigation of the patients was carried out early, but in more than a third of the medical records there was no description of investigation of other household contacts. Half of the patients lost follow-up throughout treatment. The therapy was safe and the socioeconomic analysis was impaired because there was no data in the medical record.

Keywords

• tuberculosis
• latent tuberculosis
• pediatrics
• lost to follow-up