Multifunctional wound dressing for highly efficient treatment of chronic diabetic wounds
Tengfei Ma,
Xinyun Zhai,
Mengdie Jin,
Yongkang Huang,
Mengzhen Zhang,
Haobo Pan,
Xiaoli Zhao,
Yaping Du
Affiliations
Tengfei Ma
Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional Materials School of Materials Science and Engineering National Institute for Advanced Materials Nankai University Tianjin China
Xinyun Zhai
Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional Materials School of Materials Science and Engineering National Institute for Advanced Materials Nankai University Tianjin China
Mengdie Jin
Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional Materials School of Materials Science and Engineering National Institute for Advanced Materials Nankai University Tianjin China
Yongkang Huang
College of Chemistry Nankai University Tianjin China
Mengzhen Zhang
College of Chemistry Nankai University Tianjin China
Haobo Pan
Research Center for Human Tissue and Organs Degeneration Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen China
Xiaoli Zhao
Research Center for Human Tissue and Organs Degeneration Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen China
Yaping Du
Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional Materials School of Materials Science and Engineering National Institute for Advanced Materials Nankai University Tianjin China
Abstract As the number of diabetics increases yearly and diabetic ulcer is the most concerned diabetic complication, it is of great urgency to develop a novel multifunctional material with high efficiency to promote diabetic wound healing. In this paper, ceria (CeO2)‐modified upconversion nanoparticles which loaded in polycaprolactone membranes were successfully prepared as a ceria‐based wound dressing for chronic wound healing. In this system, near‐infrared (NIR) light is used as a switch to control the photodynamic antibacterial therapy by converting the NIR photons into ultraviolet light, which can further trigger CeO2 to produce reactive oxygen species. In addition, the well‐known antioxidant ability of CeO2 endows the wound dressing with prominent capability to resist the oxidative stress around chronic wounds. In summary, both photodynamic antibacterial therapy and good antioxidant property are realized simultaneously in this CeO2‐based system to promote the healing of diabetic chronic wounds.
