Human Vaccines & Immunotherapeutics (Jan 2021)

Concomitant medications and immune checkpoint inhibitor therapy for cancer: causation or association?

  • Nadiya Hussain,
  • Muntaha Naeem,
  • David J. Pinato

DOI
https://doi.org/10.1080/21645515.2020.1769398
Journal volume & issue
Vol. 17, no. 1
pp. 55 – 61

Abstract

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The majority of cancer patients assume concomitant medications for the treatment of cancer-related symptoms or co-morbidities. As immune checkpoint inhibitors expand in the treatment of a widening range of malignancies, drug–drug interactions have become an area of increasing interest due to the potential for some concomitant medications to exert immune-modulatory effects and influence outcomes from immunotherapy. Here, we review the evidence supporting this association across selected drug classes including antibiotics, proton pump inhibitors, metformin, and opioids.

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