EJC Skin Cancer (Jan 2023)
CLAUDIUS Study: Risk of materno-fetal transmission of melanoma cells in pregnant women with high grade melanoma – A retrospective multicenter study and literature review
- Svenja Vanessa Wiedemann,
- Verena Müller,
- Bettina Toth,
- Michael Erdmann,
- Bodo Bühler,
- Susanne Dugas-Breit,
- Kerstin Schatton,
- Lydia Reinhardt,
- Markus Meissner,
- Marion Mickler,
- Claudia Pföhler,
- Carsten Weishaupt,
- Rudolf Herbst,
- Dirk Debus,
- Laura Susok,
- Julia Katharina Tietze,
- Julia Welzel,
- Andreas Arnold,
- Evelyn Dabrowski,
- Andrea Forschner,
- Steven Goetze,
- Kinan Hayani,
- Céleste Lebbe,
- Florian Löhr,
- Miriam Mengoni,
- Barbara Hermes,
- Wiebke Katharina Peitsch,
- Gabriela Poch,
- Michael Max Sachse,
- Anca Sindrilaru,
- Saskia Wenk,
- Mirjana Ziemer,
- Kjell Kaune,
- Lisette Meier-Naust,
- Georgios Nikolakis,
- Florian Oberndörfer,
- Ulrich Wesselmann,
- Jochen Sven Utikal,
- Maria Rita Gaiser
Affiliations
- Svenja Vanessa Wiedemann
- Department of Dermatology, Venerology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany
- Verena Müller
- Department of Dermatology, Venerology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany
- Bettina Toth
- Department of Gynecological Endocrinology and Reproductive Medicine, Medical University Innsbruck, Innsbruck, Austria
- Michael Erdmann
- Department of Dermatology, University Hospital Erlangen, Comprehensive Cancer Center Erlangen – European Metropolitan Area of Nuremberg (CCC-EMN), Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
- Bodo Bühler
- Department of Dermatology and Allergology and Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany
- Susanne Dugas-Breit
- Department of Dermatology, Fachklinik Hornheide, Münster, Germany
- Kerstin Schatton
- Department of Dermatology, Heinrich-Heine University Medical Faculty Duesseldorf, Duesseldorf, Germany
- Lydia Reinhardt
- Department of Dermatology, University Hospital and Medical Faculty Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
- Markus Meissner
- Department of Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany
- Marion Mickler
- Department of Dermatology, University Hospital Regensburg, Regensburg, Germany
- Claudia Pföhler
- Department of Dermatology, Saarland University Medical Center, Homburg, Saarland, Germany
- Carsten Weishaupt
- Department of Dermatology, University Hospital Muenster, Muenster, Germany
- Rudolf Herbst
- Department of Dermatology, Helios Skin Cancer Center, Helios Hospital Erfurt, Erfurt, Germany
- Dirk Debus
- Skin Center, Department of Dermatology, Paracelsus Medical University, General Hospital Nuremberg, Nuremberg, Germany
- Laura Susok
- Department of Dermatology, Venereology and Allergology, University Medical Center Bochum, Ruhr-University of Bochum, Bochum, Germany
- Julia Katharina Tietze
- Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany
- Julia Welzel
- Department of Dermatology, University Hospital Augsburg, Augsburg, Germany
- Andreas Arnold
- Skin Cancer Center, Department of Dermatology, Universitätsmedizin Greifswald, Greifswald, Germany
- Evelyn Dabrowski
- Department of Dermatology, Ludwigshafen Medical Center, Ludwigshafen, Germany
- Andrea Forschner
- Department of Dermatology, University Hospital, Eberhards-Karl-University Tübingen, Tübingen, Germany
- Steven Goetze
- Department of Dermatology, University Medical Center, Friedrich-Schiller-University of Jena, Jena, Germany
- Kinan Hayani
- Department of Dermatology and Allergy, University Hospital of Munich (LMU), Munich, Germany
- Céleste Lebbe
- Institut du cancer AP-HP. Nord – Université Paris Cité Dermato-Oncology Hôpital Saint Louis, INSERM U976, Paris, France
- Florian Löhr
- Department of Experimental Dermatology and Allergology, University of Oldenburg, Oldenburg, Germany
- Miriam Mengoni
- Department of Dermatology, University Hospital Magdeburg, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany
- Barbara Hermes
- Department of Dermatology and Phlebology, Vivantes Klinikum im Friedrichshain, Berlin, Germany
- Wiebke Katharina Peitsch
- Department of Dermatology and Phlebology, Vivantes Klinikum im Friedrichshain, Berlin, Germany
- Gabriela Poch
- Department of Dermatology, Venereology and Allergology, Charité, Universitätsmedizin Berlin, Berlin, Germany
- Michael Max Sachse
- Department of Dermatology, Allergology and Phlebology, Hospital Bremerhaven-Reinkenheide, Bremerhaven, Germany
- Anca Sindrilaru
- Skin Cancer Center, Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany
- Saskia Wenk
- Department of Dermatology, Venereology and Allergology, Klinikum Darmstadt, Darmstadt, Germany
- Mirjana Ziemer
- Department of Dermatology, Venereology and Allergology, University Medical Center Leipzig, Leipzig, Germany
- Kjell Kaune
- Department of Dermatology and Allergology, Klinikum Bremen-Ost, Bremen, Germany
- Lisette Meier-Naust
- Department of Dermatology, Venerology, Allergology and Phlebology, University Medical Center Minden, Ruhr-University of Bochum, Minden, Germany
- Georgios Nikolakis
- Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane, Dessau, Germany
- Florian Oberndörfer
- Department of Dermatology, Helios-Klinikum Hildesheim, Hildesheim, Germany
- Ulrich Wesselmann
- Department of Dermatology, Helios University Hospital Wuppertal, Wuppertal, Germany
- Jochen Sven Utikal
- Department of Dermatology, Venerology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany
- Maria Rita Gaiser
- Department of Dermatology, Venerology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany; Correspondence to: Skin Cancer Unit, Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
- Journal volume & issue
-
Vol. 1
p. 100005
Abstract
Background: Vertical transmission of maternal cancer cells to the child is extremely rare, but melanoma represents the most common culprit. The aim of this study is to determine individual risks for materno-fetal transmission of melanoma cells and to establish standardized procedures for pregnant melanoma patients and their offspring. Patients and methods: In this retrospective multicenter study, data on women with stage III or IV melanoma that had been diagnosed before, during or up to 12 months after pregnancy, were analyzed for the occurrence of metastases in the placenta or the infant. In addition, a literature search for previously described materno-fetal transmission in case of maternal melanoma was conducted. A historical patient group was established from these cases and a statistical analysis was performed (SAS, p < 0.05 significant). Results: In total, 67 children born to women with stage III or IV melanoma were included. No placental or infant metastases were detected in any of the cases. The additional literature search revealed 37 cases with placental metastases and 14 cases with infant metastases (6 of them overlapping). Of the affected children, 10 (71.43%) died from their disease. Maternal death shortly after birth seems to be an unfavorable factor for transmission to the infant. Conclusion: The risk of materno-fetal transmission of maternal melanoma metastases seems to be much lower than anticipated based on former studies. However, thorough placental screening and systematic follow-up of the children resulting from pregnancies of high-risk melanoma patients should be performed.
