Nature Communications (May 2022)
BMP4 drives primed to naïve transition through PGC-like state
- Shengyong Yu,
- Chunhua Zhou,
- Jiangping He,
- Zhaokai Yao,
- Xingnan Huang,
- Bowen Rong,
- Hong Zhu,
- Shijie Wang,
- Shuyan Chen,
- Xialian Wang,
- Baomei Cai,
- Guoqing Zhao,
- Yuhan Chen,
- Lizhan Xiao,
- He Liu,
- Yue Qin,
- Jing Guo,
- Haokaifeng Wu,
- Zhen Zhang,
- Man Zhang,
- Xiaoyang Zhao,
- Fei Lan,
- Yixuan Wang,
- Jiekai Chen,
- Shangtao Cao,
- Duanqing Pei,
- Jing Liu
Affiliations
- Shengyong Yu
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Chunhua Zhou
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Jiangping He
- Center for Cell Lineage and Atlas, Bioland Laboratory
- Zhaokai Yao
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Xingnan Huang
- Laboratory of Cell Fate Control, School of Life Sciences, Westlake University
- Bowen Rong
- Shanghai Key Laboratory of Medical Epigenetics, State International Co-laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University
- Hong Zhu
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Shijie Wang
- GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University
- Shuyan Chen
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Xialian Wang
- GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University
- Baomei Cai
- Center for Cell Lineage and Atlas, Bioland Laboratory
- Guoqing Zhao
- Center for Cell Lineage and Atlas, Bioland Laboratory
- Yuhan Chen
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Lizhan Xiao
- Center for Cell Lineage and Atlas, Bioland Laboratory
- He Liu
- Center for Cell Lineage and Atlas, Bioland Laboratory
- Yue Qin
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Jing Guo
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Haokaifeng Wu
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Zhen Zhang
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Man Zhang
- Center for Cell Lineage and Atlas, Bioland Laboratory
- Xiaoyang Zhao
- State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University
- Fei Lan
- Shanghai Key Laboratory of Medical Epigenetics, State International Co-laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University
- Yixuan Wang
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Jiekai Chen
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Shangtao Cao
- Center for Cell Lineage and Atlas, Bioland Laboratory
- Duanqing Pei
- Laboratory of Cell Fate Control, School of Life Sciences, Westlake University
- Jing Liu
- Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-022-30325-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Multiple pluripotent states have been described in mouse and human stem cells. Here the authors describe trajectories during BMP4 induced primed to naïve transition, which bifurcates into naïve and trophoblast-like branches with a PGC-like intermediate at the naïve branch.
