Nature Communications (Jan 2020)
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
- Nikos Papadimitriou,
- Niki Dimou,
- Konstantinos K. Tsilidis,
- Barbara Banbury,
- Richard M. Martin,
- Sarah J. Lewis,
- Nabila Kazmi,
- Timothy M. Robinson,
- Demetrius Albanes,
- Krasimira Aleksandrova,
- Sonja I. Berndt,
- D. Timothy Bishop,
- Hermann Brenner,
- Daniel D. Buchanan,
- Bas Bueno-de-Mesquita,
- Peter T. Campbell,
- Sergi Castellví-Bel,
- Andrew T. Chan,
- Jenny Chang-Claude,
- Merete Ellingjord-Dale,
- Jane C. Figueiredo,
- Steven J. Gallinger,
- Graham G. Giles,
- Edward Giovannucci,
- Stephen B. Gruber,
- Andrea Gsur,
- Jochen Hampe,
- Heather Hampel,
- Sophia Harlid,
- Tabitha A. Harrison,
- Michael Hoffmeister,
- John L. Hopper,
- Li Hsu,
- José María Huerta,
- Jeroen R. Huyghe,
- Mark A. Jenkins,
- Temitope O. Keku,
- Tilman Kühn,
- Carlo La Vecchia,
- Loic Le Marchand,
- Christopher I. Li,
- Li Li,
- Annika Lindblom,
- Noralane M. Lindor,
- Brigid Lynch,
- Sanford D. Markowitz,
- Giovanna Masala,
- Anne M. May,
- Roger Milne,
- Evelyn Monninkhof,
- Lorena Moreno,
- Victor Moreno,
- Polly A. Newcomb,
- Kenneth Offit,
- Vittorio Perduca,
- Paul D. P. Pharoah,
- Elizabeth A. Platz,
- John D. Potter,
- Gad Rennert,
- Elio Riboli,
- Maria-Jose Sánchez,
- Stephanie L. Schmit,
- Robert E. Schoen,
- Gianluca Severi,
- Sabina Sieri,
- Martha L. Slattery,
- Mingyang Song,
- Catherine M. Tangen,
- Stephen N. Thibodeau,
- Ruth C. Travis,
- Antonia Trichopoulou,
- Cornelia M. Ulrich,
- Franzel J. B. van Duijnhoven,
- Bethany Van Guelpen,
- Pavel Vodicka,
- Emily White,
- Alicja Wolk,
- Michael O. Woods,
- Anna H. Wu,
- Ulrike Peters,
- Marc J. Gunter,
- Neil Murphy
Affiliations
- Nikos Papadimitriou
- Section of Nutrition and Metabolism, International Agency for Research on Cancer
- Niki Dimou
- Section of Nutrition and Metabolism, International Agency for Research on Cancer
- Konstantinos K. Tsilidis
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine
- Barbara Banbury
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Richard M. Martin
- MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol
- Sarah J. Lewis
- Bristol Medical School, Department of Population Health Sciences, University of Bristol
- Nabila Kazmi
- MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol
- Timothy M. Robinson
- Bristol Medical School, Department of Population Health Sciences, University of Bristol
- Demetrius Albanes
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Krasimira Aleksandrova
- German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- D. Timothy Bishop
- Leeds Institute of Cancer and Pathology, University of Leeds
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Daniel D. Buchanan
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Bas Bueno-de-Mesquita
- Former senior scientist, Dept. for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1
- Peter T. Campbell
- Behavioral and Epidemiology Research Group, American Cancer Society
- Sergi Castellví-Bel
- Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona
- Andrew T. Chan
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School
- Jenny Chang-Claude
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Merete Ellingjord-Dale
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Jane C. Figueiredo
- Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Steven J. Gallinger
- Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto
- Graham G. Giles
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Edward Giovannucci
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University
- Stephen B. Gruber
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
- Andrea Gsur
- Institute of Cancer Research, Department of Medicine I, Medical University Vienna
- Jochen Hampe
- Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- Heather Hampel
- Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center
- Sophia Harlid
- Department of Radiation Sciences, Oncology, Umea University
- Tabitha A. Harrison
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Michael Hoffmeister
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- John L. Hopper
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Li Hsu
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- José María Huerta
- CIBER de Epidemiología y Salud Pública (CIBERESP)
- Jeroen R. Huyghe
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Mark A. Jenkins
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Temitope O. Keku
- Center for Gastrointestinal Biology and Disease, University of North Carolina
- Tilman Kühn
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Carlo La Vecchia
- Hellenic Health Foundation
- Loic Le Marchand
- University of Hawaii Cancer Center
- Christopher I. Li
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Li Li
- Department of Family Medicine, University of Virginia
- Annika Lindblom
- Department of Clinical Genetics, Karolinska University Hospital
- Noralane M. Lindor
- Department of Health Science Research, Mayo Clinic
- Brigid Lynch
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Sanford D. Markowitz
- Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, and University Hospitals of Cleveland
- Giovanna Masala
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO
- Anne M. May
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500
- Roger Milne
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Evelyn Monninkhof
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500
- Lorena Moreno
- Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona
- Victor Moreno
- CIBER de Epidemiología y Salud Pública (CIBERESP)
- Polly A. Newcomb
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Kenneth Offit
- Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center
- Vittorio Perduca
- CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-Saclay
- Paul D. P. Pharoah
- Department of Public Health and Primary Care, University of Cambridge
- Elizabeth A. Platz
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- John D. Potter
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Gad Rennert
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center
- Elio Riboli
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Maria-Jose Sánchez
- CIBER de Epidemiología y Salud Pública (CIBERESP)
- Stephanie L. Schmit
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
- Robert E. Schoen
- Department of Medicine and Epidemiology, University of Pittsburgh Medical Center
- Gianluca Severi
- CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-Saclay
- Sabina Sieri
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori
- Martha L. Slattery
- Department of Internal Medicine, University of Utah
- Mingyang Song
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School
- Catherine M. Tangen
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center
- Stephen N. Thibodeau
- Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic
- Ruth C. Travis
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford
- Antonia Trichopoulou
- Hellenic Health Foundation
- Cornelia M. Ulrich
- Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah
- Franzel J. B. van Duijnhoven
- Division of Human Nutrition, Wageningen University and Research
- Bethany Van Guelpen
- Department of Radiation Sciences, Oncology Unit, Umeå University
- Pavel Vodicka
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences
- Emily White
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Alicja Wolk
- Institute of Environmental Medicine, Karolinska Institutet
- Michael O. Woods
- Memorial University of Newfoundland, Discipline of Genetics
- Anna H. Wu
- University of Southern California, Preventative Medicine
- Ulrike Peters
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Marc J. Gunter
- Section of Nutrition and Metabolism, International Agency for Research on Cancer
- Neil Murphy
- Section of Nutrition and Metabolism, International Agency for Research on Cancer
- DOI
- https://doi.org/10.1038/s41467-020-14389-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.
