Communications Biology (Oct 2022)

A comprehensive transcriptomic comparison of hepatocyte model systems improves selection of models for experimental use

  • Arif Ibrahim Ardisasmita,
  • Imre F. Schene,
  • Indi P. Joore,
  • Gautam Kok,
  • Delilah Hendriks,
  • Benedetta Artegiani,
  • Michal Mokry,
  • Edward E. S. Nieuwenhuis,
  • Sabine A. Fuchs

DOI
https://doi.org/10.1038/s42003-022-04046-9
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 15

Abstract

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A systematic comparison of transcriptomes across different hepatocyte models provides a valuable resource to determine the most suitable model for a particular application or research question.