Frontiers in Immunology (Jan 2021)
Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients
- Lili Li,
- Lili Li,
- Jie Li,
- Meiling Gao,
- Meiling Gao,
- Meiling Gao,
- Huimin Fan,
- Huimin Fan,
- Yanan Wang,
- Xin Xu,
- Xin Xu,
- Chunfeng Chen,
- Junxiao Liu,
- Junxiao Liu,
- Jocelyn Kim,
- Roghiyh Aliyari,
- Jicai Zhang,
- Yujie Jin,
- Xiaorong Li,
- Xiaorong Li,
- Feng Ma,
- Feng Ma,
- Minxin Shi,
- Genhong Cheng,
- Heng Yang,
- Heng Yang
Affiliations
- Lili Li
- Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
- Lili Li
- Cheng Lab, Suzhou Institute of Systems Medicine, Suzhou, China
- Jie Li
- Department of Laboratory Medicine, TaiHe Hospital, Hubei University of Medicine, Shiyan, China
- Meiling Gao
- Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
- Meiling Gao
- Cheng Lab, Suzhou Institute of Systems Medicine, Suzhou, China
- Meiling Gao
- Department of Laboratory Medicine, TaiHe Hospital, Hubei University of Medicine, Shiyan, China
- Huimin Fan
- Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
- Huimin Fan
- Cheng Lab, Suzhou Institute of Systems Medicine, Suzhou, China
- Yanan Wang
- Department of Scientific Research, Suzhou Func Biotech Inc, Suzhou, China
- Xin Xu
- Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
- Xin Xu
- Cheng Lab, Suzhou Institute of Systems Medicine, Suzhou, China
- Chunfeng Chen
- Department of Scientific Research, Suzhou Func Biotech Inc, Suzhou, China
- Junxiao Liu
- Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
- Junxiao Liu
- Cheng Lab, Suzhou Institute of Systems Medicine, Suzhou, China
- Jocelyn Kim
- Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States
- Roghiyh Aliyari
- Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States
- Jicai Zhang
- Department of Laboratory Medicine, TaiHe Hospital, Hubei University of Medicine, Shiyan, China
- Yujie Jin
- Department of Laboratory Medicine, TaiHe Hospital, Hubei University of Medicine, Shiyan, China
- Xiaorong Li
- Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
- Xiaorong Li
- Cheng Lab, Suzhou Institute of Systems Medicine, Suzhou, China
- Feng Ma
- Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
- Feng Ma
- Cheng Lab, Suzhou Institute of Systems Medicine, Suzhou, China
- Minxin Shi
- Department of Surgery, Affiliated Tumor Hospital of Nantong University, Nantong, China
- Genhong Cheng
- Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States
- Heng Yang
- Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
- Heng Yang
- Cheng Lab, Suzhou Institute of Systems Medicine, Suzhou, China
- DOI
- https://doi.org/10.3389/fimmu.2020.602395
- Journal volume & issue
-
Vol. 11
Abstract
The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis.
Keywords
- cytokine serum profile
- biomarker
- coronavirus disease-2019 prognosis
- respiratory syndrome coronavirus 2
- cytokine storm
- interleukin-6
