Korean Registry on the Current Management of Helicobacter pylori (K-Hp-Reg): Interim Analysis of Adherence to the Revised Evidence-Based Guidelines for First-Line Treatment
Hyo-Joon Yang,
Joon Sung Kim,
Ji Yong Ahn,
Ok-Jae Lee,
Gwang Ha Kim,
Chang Seok Bang,
Moo In Park,
Jae Yong Park,
Sun Moon Kim,
Su Jin Hong,
Joon Hyun Cho,
Shin Hee Kim,
Hyun Joo Song,
Jin Woong Cho,
Sam Ryong Jee,
Hyun Lim,
Yong Hwan Kwon,
Ju Yup Lee,
Seong Woo Jeon,
Seon-Young Park,
Younghee Choe,
Moon Kyung Joo,
Dae-Hyun Kim,
Jae Myung Park,
Beom Jin Kim,
Jong Yeul Lee,
Tae Hoon Oh,
Jae Gyu Kim,
Korean College of Helicobacter and Upper Gastrointestinal Research
Affiliations
Hyo-Joon Yang
Division of Gastroenterology, Department of Internal Medicine and Gastrointestinal Cancer Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
Joon Sung Kim
Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Ji Yong Ahn
Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Ok-Jae Lee
Department of Internal Medicine, Gyeongsang National University College of Medicine and Institute of Medical Science, Gyeongsang National University, Jinju, Korea
Gwang Ha Kim
Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
Chang Seok Bang
Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea
Moo In Park
Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea
Jae Yong Park
Division of Gastroenterology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea
Sun Moon Kim
Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea
Su Jin Hong
Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea
Joon Hyun Cho
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea
Shin Hee Kim
Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea
Hyun Joo Song
Department of Internal Medicine, Jeju National University College of Medicine, Jeju, Korea
Jin Woong Cho
Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea
Sam Ryong Jee
Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea
Hyun Lim
Department of Gastroenterology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
Yong Hwan Kwon
Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
Ju Yup Lee
Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
Seong Woo Jeon
Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
Seon-Young Park
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
Younghee Choe
Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Moon Kyung Joo
Division of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
Dae-Hyun Kim
Ulsan Comfort Gastroenterology Clinic, Ulsan, Korea
Jae Myung Park
Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Beom Jin Kim
Division of Gastroenterology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea
Jong Yeul Lee
Center for Gastric Cancer, National Cancer Center, Goyang, Korea
Tae Hoon Oh
Department of Internal Medicine, Vievis Namuh Hospital, Seoul, Korea
Jae Gyu Kim
Division of Gastroenterology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea
Korean College of Helicobacter and Upper Gastrointestinal Research
Background/Aims: The Korean guidelines for Helicobacter pylori treatment were revised in 2020, however, the extent of adherence to these guidelines in clinical practice remains unclear. Herein, we initiated a prospective, nationwide, multicenter registry study in 2021 to evaluate the current management of H. pylori infection in Korea. Methods: This interim report describes the adherence to the revised guidelines and their impact on first-line eradication rates. Data on patient demographics, diagnoses, treatments, and eradication outcomes were collected using a web-based electronic case report form. Results: A total of 7,261 patients from 66 hospitals who received first-line treatment were analyzed. The modified intention-to-treat eradication rate for first-line treatment was 81.0%, with 80.4% of the prescriptions adhering to the revised guidelines. The most commonly prescribed regimen was the 14-day clarithromycin-based triple therapy (CTT; 42.0%), followed by tailored therapy (TT; 21.2%), 7-day CTT (14.1%), and 10-day concomitant therapy (CT; 10.1%). Time-trend analysis demonstrated significant increases in guideline adherence and the use of 10-day CT and TT, along with a decrease in the use of 7-day CTT (all p<0.001). Multivariate logistic regression analysis revealed that guideline adherence was significantly associated with first-line eradication success (odds ratio, 2.03; 95% confidence interval, 1.61 to 2.56; p<0.001). Conclusions: The revised guidelines for the treatment of H. pylori infection have been increasingly adopted in routine clinical practice in Korea, which may have contributed to improved first-line eradication rates. Notably, the 14-day CTT, 10-day CT, and TT regimens are emerging as the preferred first-line treatment options among Korean physicians.
