A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells

Viviana Volta; Sandra Pérez-Baos; Columba de la Parra; Olga Katsara; Amanda Ernlund; Sophie Dornbaum; Robert J. Schneider

doi:10.1038/s41467-021-27087-w

Nature Communications (Nov 2021)

A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells

Viviana Volta,
Sandra Pérez-Baos,
Columba de la Parra,
Olga Katsara,
Amanda Ernlund,
Sophie Dornbaum,
Robert J. Schneider

Affiliations

Viviana Volta: Synthis LLC, 430 East 29th Street, Launch Labs, Alexandria Center for Life Sciences
Sandra Pérez-Baos: Department of Microbiology, NYU Grossman School of Medicine
Columba de la Parra: Department of Chemistry, Herbert H. Lehman College, City University of New York, The Graduate Center, Biochemistry Ph.D. Program, City University of New York
Olga Katsara: Department of Microbiology, NYU Grossman School of Medicine
Amanda Ernlund: Johns Hopkins Applied Physics Lab
Sophie Dornbaum: Department of Microbiology, NYU Grossman School of Medicine
Robert J. Schneider: Department of Microbiology, NYU Grossman School of Medicine

DOI: https://doi.org/10.1038/s41467-021-27087-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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The differentiation of naive T cells to immune suppressing induced regulatory T (iTreg) cells requires TGF-beta-1 and downregulation of mTORC1 activity, which inhibits mRNA translation. Here the authors show that iTreg cell differentiation uses an alternate mRNA translation mechanism involving translation factors DAP5 and eIF3d.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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