The effect of vitamin B6 on the breast pain in first trimester of pregnancy in pregnant women referring to the comprehensive health centers in Gonabad, 2019-2020

Abstract

Introduction: The first trimester of pregnancy is associated with unpleasant experiences for mothers. One of these unpleasant experiences is breast pain, which leads to a low quality of life in pregnant women, so the present study was conducted with aim to investigate the effect of vitamin B6 as a safe and available supplement on breast pain in the first trimester of pregnancy. Methods: This randomized controlled clinical trial study was conducted in 2019-2020 on women with a gestational age of 6-10 weeks who had breast pain with start of pregnancy for 5 days or more in Gonabad city. Pregnant women were divided into two groups of 42 people, control and intervention. The control group was given a placebo daily and the intervention group was given a 40 mg vitamin B6 pill for 1 month. The visual pain scale questionnaire was given to the research units before and one month after the intervention. The amounts of vitamin B6 received from the diet of the groups were obtained through a 24-hour food reminder questionnaire and N4 software. Data analysis was done using SPSS software (version 20) and independent t-tests, Mann-Whitney, Chi-square, Fisher, Wilcoxon and regression. P0.05). According to Mann-Whitney test results, there was no significant difference between the two groups regarding the mean score of breast pain after the intervention (p=0.2). Conclusion: The effect of oral vitamin B6 compared to placebo is not effective on reducing breast pain score in the first trimester of pregnancy. Further studies with a larger sample size, different doses of vitamin B6 and measuring the serum level of vitamin B6 are suggested.

Keywords

• breast pain
• pregnancy
• vitamin b6