Frontiers in Oncology (Feb 2025)

SMARCA4-deficient undifferentiated carcinoma co-existing with primary endometrial gastric (or gastrointestinal) -type carcinoma: a case report

  • Fan Yang,
  • Haixiao Fu,
  • Xiang Zheng,
  • Yuzhong Yang,
  • Quyan Zhou,
  • Yuanna Liang,
  • Jinhua Zheng,
  • Jing Lin

DOI
https://doi.org/10.3389/fonc.2025.1510930
Journal volume & issue
Vol. 15

Abstract

Read online

Dedifferentiated endometrial carcinoma (DEC) is a rare and highly malignant endometrial tumor consisting of both undifferentiated endometrial carcinoma (UEC) and differentiated components (that are typically grade 1 or 2 endometrioid carcinomas). By contrast, the coexistence of UEC with a high-grade endometrial carcinoma has not been well reported. Primary endometrial gastric (gastrointestinal)-type carcinoma (PEGT-carcinoma) is a newly classified and rare type of female genital tract cancer, this neoplasm belongs to high-grade endometrial carcinoma and tends to have a poor outcome. In this study, we reported an atypical case of DEC composed of SMARCA4-deficient UEC and PEGT-carcinoma and reviewed its clinicopathological features.

Keywords