Advances in the role of follicular T helper cells in graft versus host diseases

Maogen Chen; Xiaohong Lin; Julie Wang; Nancy Olsen; Song Guo Zheng

Liver Research (Sep 2017)

Advances in the role of follicular T helper cells in graft versus host diseases

Maogen Chen,
Xiaohong Lin,
Julie Wang,
Nancy Olsen,
Song Guo Zheng

Affiliations

Maogen Chen: Division of Immunology and Rheumatology, Keck School of Medicine at University of Southern California, CA, USA; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, China; Center for Clinical Immunology at Sun Yat-sen University, Guangzhou, China
Xiaohong Lin: Division of General Surgery, The Eastern Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Julie Wang: Division of Rheumatology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA
Nancy Olsen: Division of Rheumatology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA
Song Guo Zheng: Division of Immunology and Rheumatology, Keck School of Medicine at University of Southern California, CA, USA; Center for Clinical Immunology at Sun Yat-sen University, Guangzhou, China; Division of Rheumatology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA; Corresponding author. Division of Rheumatology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.

Journal volume & issue: Vol. 1, no. 2
pp. 131 – 134

Abstract

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Graft versus host disease (GVHD) is a refractory complication of allogeneic hematopoietic stem cell transplantation for the treatment of malignant and non-malignant hematopoietic diseases. Inflammatory cascade responses and cellular immune reactions are the major factors underlying GVHD pathogenesis. Cells producing the cytokine, interleukin (IL)-21 are crucial players involved in injured tissues in GVHD patients. Besides T helper 17 cells, follicular T helper (Tfh) cells are a new source of IL-21 and play a vital role in GVHD pathogenesis. Tfh cell function is mostly regulated by T-follicular regulatory (Tfr) cells that are also located in the germinal center. This review highlights recent advances in the role of Tfh and Tfr cell function in GVHD pathogenesis. New insights are provided into the potential for clinical application in GVHD prevention and treatment. Keywords: Graft versus host disease (GVHD), Allogeneic hematopoietic stem cell transplantation, Interleukin-21, Follicular T helper (Tfh) cell

Published in Liver Research

ISSN: 2096-2878 (Print); 2542-5684 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.keaipublishing.com/en/journals/liver-research/

About the journal