Two new phenylpropanoid glycosides from the aerial parts of Lespedeza cuneata

Abstract

Two new phenylpropanoid glycosides named cuneataside E (1) and cuneataside F (2), were isolated from the aerial parts of Lespedeza cuneata (Dum. Cours.) G. Don, whose structures were E and Z isomer, respectively. Their structures were elucidated on the basis of comprehensive spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR). In in vitro bioassays at 10 μmol/L, compound 1 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HeG2 cells.

Keywords

• Lespedeza cuneata
• Phenylpropanoid glycosides
• Extraction and isolation
• Hepatoprotective activity
• Cuneataside E
• Cuneataside F