Neurobiology of Disease (Apr 2001)
Seasonal Affective Disorder and Serotonin-Related Polymorphisms
- C. Johansson,
- C. Smedh,
- T. Partonen,
- P. Pekkarinen,
- T. Paunio,
- J. Ekholm,
- L. Peltonen,
- D. Lichtermann,
- J. Palmgren,
- R. Adolfsson,
- M. Schalling
Affiliations
- C. Johansson
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- C. Smedh
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- T. Partonen
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- P. Pekkarinen
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- T. Paunio
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- J. Ekholm
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- L. Peltonen
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- D. Lichtermann
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- J. Palmgren
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- R. Adolfsson
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- M. Schalling
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet and Karolinska Hospital, S-171 76, Stockholm, Sweden; Department of Clinical Sciences, Division of Psychiatry, University of Umeå, S-901 85, Umeå, Sweden; Department of Mental Health and Alcohol Research, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Human Molecular Genetics, National Public Health Institute, FIN-00300, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, FIN-00014, Helsinki, Finland; Department of Psychiatry, University of Bonn, D-53105, Bonn, Germany; Department of Mathematical Statistics, Stockholm University, S-106 91, Stockholm, Sweden; Department of Medical Epidemiology, Karolinska Institutet, P.O. Box 281, S-171 77, Stockholm, Sweden
- Journal volume & issue
-
Vol. 8,
no. 2
pp. 351 – 357
Abstract
Disturbances in central serotonergic systems have been hypothesized to be involved in seasonal affective disorder (SAD). Association between SAD and the shorter allele of the serotonin transporter promoter repeat length polymorphism (5-HTTLPR) has been reported in an American sample. We have genotyped 82 SAD patients and 82 healthy controls from Sweden, Finland, and Germany for this and five other polymorphisms in the genes coding for serotonin receptors 5-HT2A and 5-HT2C, tryptophan hydroxylase and white. No associations with SAD or seasonality (seasonal variations in mood and behavior) were detected. Although minor effects cannot be excluded, our results suggest that these polymorphisms do not play a major role in the pathogenesis of SAD in the northern European population.
