Nature Communications (Dec 2020)
Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment
- Yingxia Zheng,
- Zheyi Chen,
- Yichao Han,
- Li Han,
- Xin Zou,
- Bingqian Zhou,
- Rui Hu,
- Jie Hao,
- Shihao Bai,
- Haibo Xiao,
- Wei Vivian Li,
- Alex Bueker,
- Yanhui Ma,
- Guohua Xie,
- Junyao Yang,
- Shiyu Chen,
- Hecheng Li,
- Jian Cao,
- Lisong Shen
Affiliations
- Yingxia Zheng
- Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- Zheyi Chen
- Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- Yichao Han
- Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Li Han
- Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- Xin Zou
- Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University
- Bingqian Zhou
- Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- Rui Hu
- Department of Thoracic Surgery, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- Jie Hao
- Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University
- Shihao Bai
- Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University
- Haibo Xiao
- Department of Thoracic Surgery, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- Wei Vivian Li
- Department of Biostatistics and Epidemiology, Rutgers School of Public Health
- Alex Bueker
- Rutgers Cancer Institute of New Jersey
- Yanhui Ma
- Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- Guohua Xie
- Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- Junyao Yang
- Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- Shiyu Chen
- Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- Hecheng Li
- Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Jian Cao
- Rutgers Cancer Institute of New Jersey
- Lisong Shen
- Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-20019-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Understanding the tumour microenvironment is essential for the efficacy of immunotherapies. Here the authors describe the immune landscape in esophageal squamous cell carcinoma and suggest several immunosuppressive mechanisms, which upon targeting may restore anti-tumour immune response.
