BMC Psychiatry (Sep 2024)

Association of electronic cigarette use and suicidal behaviors: a systematic review and meta-analysis

  • Abdelaziz A. Awad,
  • Ramaiah Itumalla,
  • Abhay M. Gaidhane,
  • Mahalaqua Nazli Khatib,
  • Suhas Ballal,
  • Pooja Bansal,
  • Manish Srivastava,
  • Isha Arora,
  • MRavi Kumar,
  • Aashna Sinha,
  • Kumud Pant,
  • Hashem Abu Serhan,
  • Muhammed Shabil

DOI
https://doi.org/10.1186/s12888-024-06012-7
Journal volume & issue
Vol. 24, no. 1
pp. 1 – 11

Abstract

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Abstract Background The proliferation of electronic cigarettes (e-cigarettes) has presented new challenges in public health, particularly among adolescents and young adults. While marketed as safer than tobacco and as cessation aids, e-cigarettes have raised concerns about their long-term health and psychosocial impacts, including potential links to increased suicidal behaviors. This study aims to evaluate the relationship between e-cigarette use and suicidal behaviors by conducting a systematic review of the current literature. Methods We searched PubMed, Web of Science, and EMBASE for studies up to March 10, 2024, examining the relationship between e-cigarette use and suicidal behaviors. Eligible studies included cross-sectional, longitudinal, retrospective, prospective, and case–control designs. Meta-analysis was performed to calculate pooled odds ratios (ORs). Newcastle Ottawa scale was used to assess the quality of studies. R software (V 4.3) was used to perform the meta-analysis. Results Our analysis included fourteen studies, predominantly from the US and Korea, with participants ranging from 1,151 to 255,887. The meta-analysis identified a significant association between e-cigarette use and an increased risk of suicidal ideation (OR = 1.489, 95% CI: 1.357 to 1.621), suicide attempts (OR = 2.497, 95% CI: 1.999 to 3.996), and suicidal planning (OR = 2.310, 95% CI: 1.810 to 2.810). Heterogeneity was noted among the studies. Conclusion E-cigarette use is significantly associated with the risk of suicidal behaviors, particularly among adolescents. The findings underscore the necessity for caution in endorsing e-cigarettes as a safer smoking alternative and call for more extensive research to understand the underlying mechanisms. Public health strategies should be developed to address and mitigate the risks of suicidal behaviors among e-cigarette users.

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