mBio
(Apr 2021)
Cooperation between Different CRISPR-Cas Types Enables Adaptation in an RNA-Targeting System
Ville Hoikkala,
Janne Ravantti,
César Díez-Villaseñor,
Marja Tiirola,
Rachel A. Conrad,
Mark J. McBride,
Sylvain Moineau,
Lotta-Riina Sundberg
Affiliations
Ville Hoikkala
ORCiD University of Jyväskylä Department of Biological and Environmental Science, Nanoscience Center, Jyväskylä, Finland
Janne Ravantti
ORCiD University of Helsinki, Molecular and Integrative Biosciences Research Programme, Helsinki, Finland
César Díez-Villaseñor
University of Jyväskylä Department of Biological and Environmental Science, Nanoscience Center, Jyväskylä, Finland
Marja Tiirola
University of Jyväskylä Department of Biological and Environmental Science, Nanoscience Center, Jyväskylä, Finland
Rachel A. Conrad
University of Wisconsin—Milwaukee, Department of Biological Sciences, Milwaukee, Wisconsin, USA
Mark J. McBride
ORCiD University of Wisconsin—Milwaukee, Department of Biological Sciences, Milwaukee, Wisconsin, USA
Sylvain Moineau
ORCiD Université Laval, Département de Biochimie, de Microbiologie, et de Bio-informatique, Québec City, Québec, Canada
Lotta-Riina Sundberg
ORCiD University of Jyväskylä Department of Biological and Environmental Science, Nanoscience Center, Jyväskylä, Finland
DOI
https://doi.org/10.1128/mBio.03338-20
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
CRISPR-Cas systems are immune systems that protect bacteria and archaea against their viruses, bacteriophages. Immunity is achieved through the acquisition of short DNA fragments from the viral invader’s genome.
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