Pathohistological and immunohistochemical features of chronic viral hepatitis b progression

Abstract

Aim. The paper contains the results of a comprehensive study of pathohistological and immunohistochemical liver biopsies of 50 patients with chronic hepatitis B in relation to clinical and biochemical parameters to improve the most significant microscopic criteria of chronic hepatitis B progression in liver trepanobioptates of the patients. Methods and results. It has been established that most accurate definition of the degree of viral infection of hepatocytes in the liver trepanobioptates of the patients with chronic viral hepatitis B could be made by the immunohistochemical detection of HBsAg and HBsAg, "dull glasslike" hepatocytes revealed by microscopy not fully reflect the degree of hepatocytes’ infection. Conclusion. The presence of direct, high correlation between the number of infected hepatocytes with HBsAg and histological hepatitis activity index gives reason to use immunohistochemical labelling of HBsAg on the early stages of diagnostics in order to predict the possible progression of chronic viral hepatitis B in patients with normal level of transaminase.

Keywords

• Hepatitis B
• Chronic Liver Stellate Cells
• Fibroblasts