Molecules (Jun 2013)

Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization

  • Ke-Li Tsai,
  • Wei-Chiao Chang,
  • Mei-Hsien Lee,
  • Jaw-Yan Wang,
  • Ming-Feng Hou,
  • Yao-Ting Tsai,
  • Yii-Her Chou,
  • Siou-Jin Chiu,
  • Wen-Li Hsu,
  • Yuh-Cherng Guo,
  • Che-Mai Chang

DOI
https://doi.org/10.3390/molecules18066584
Journal volume & issue
Vol. 18, no. 6
pp. 6584 – 6596

Abstract

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Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

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