Frontiers in Neuroscience (May 2022)

Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease

  • Jaime Silva,
  • Felipe Patricio,
  • Aleidy Patricio-Martínez,
  • Aleidy Patricio-Martínez,
  • Gerardo Santos-López,
  • Lilia Cedillo,
  • Yousef Tizabi,
  • Ilhuicamina Daniel Limón

DOI
https://doi.org/10.3389/fnins.2022.867825
Journal volume & issue
Vol. 16

Abstract

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Evidence suggests that SARS-CoV-2 entry into the central nervous system can result in neurological and/or neurodegenerative diseases. In this review, routes of SARS-Cov-2 entry into the brain via neuroinvasive pathways such as transcribrial, ocular surface or hematogenous system are discussed. It is argued that SARS-Cov-2-induced cytokine storm, neuroinflammation and oxidative stress increase the risk of developing neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Further studies on the effects of SARS-CoV-2 and its variants on protein aggregation, glia or microglia activation, and blood-brain barrier are warranted.

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