Nature Communications (Jun 2023)
Patterns and determinants of the global herbivorous mycobiome
- Casey H. Meili,
- Adrienne L. Jones,
- Alex X. Arreola,
- Jeffrey Habel,
- Carrie J. Pratt,
- Radwa A. Hanafy,
- Yan Wang,
- Aymen S. Yassin,
- Moustafa A. TagElDein,
- Christina D. Moon,
- Peter H. Janssen,
- Mitesh Shrestha,
- Prajwal Rajbhandari,
- Magdalena Nagler,
- Julia M. Vinzelj,
- Sabine M. Podmirseg,
- Jason E. Stajich,
- Arthur L. Goetsch,
- Jerry Hayes,
- Diana Young,
- Katerina Fliegerova,
- Diego Javier Grilli,
- Roman Vodička,
- Giuseppe Moniello,
- Silvana Mattiello,
- Mona T. Kashef,
- Yosra I. Nagy,
- Joan A. Edwards,
- Sumit Singh Dagar,
- Andrew P. Foote,
- Noha H. Youssef,
- Mostafa S. Elshahed
Affiliations
- Casey H. Meili
- Oklahoma State University, Department of Microbiology and Molecular Genetics
- Adrienne L. Jones
- Oklahoma State University, Department of Microbiology and Molecular Genetics
- Alex X. Arreola
- Oklahoma State University, Department of Microbiology and Molecular Genetics
- Jeffrey Habel
- Oklahoma State University, Department of Microbiology and Molecular Genetics
- Carrie J. Pratt
- Oklahoma State University, Department of Microbiology and Molecular Genetics
- Radwa A. Hanafy
- Oklahoma State University, Department of Microbiology and Molecular Genetics
- Yan Wang
- Department of Biological Sciences, University of Toronto Scarborough
- Aymen S. Yassin
- Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University
- Moustafa A. TagElDein
- Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University
- Christina D. Moon
- AgResearch Ltd, Grasslands Research Centre
- Peter H. Janssen
- AgResearch Ltd, Grasslands Research Centre
- Mitesh Shrestha
- Department of Applied Microbiology and Food Technology, Research Institute for Bioscience and Biotechnology (RIBB)
- Prajwal Rajbhandari
- Department of Applied Microbiology and Food Technology, Research Institute for Bioscience and Biotechnology (RIBB)
- Magdalena Nagler
- Universität Innsbruck, Faculty of Biology, Department of Microbiology
- Julia M. Vinzelj
- Universität Innsbruck, Faculty of Biology, Department of Microbiology
- Sabine M. Podmirseg
- Universität Innsbruck, Faculty of Biology, Department of Microbiology
- Jason E. Stajich
- Department of Microbiology and Plant Pathology, University of California, Riverside
- Arthur L. Goetsch
- Langston University
- Jerry Hayes
- Langston University
- Diana Young
- Bavarian State Research Center for Agriculture
- Katerina Fliegerova
- Institute of Animal Physiology and Genetics Czech Academy of Sciences
- Diego Javier Grilli
- Área de Microbiología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo
- Roman Vodička
- Prague Zoo
- Giuseppe Moniello
- Department of Veterinary Medicine, University of Sassari
- Silvana Mattiello
- University of Milan, Dept. of Agricultural and Environmental Sciences
- Mona T. Kashef
- Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University
- Yosra I. Nagy
- Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University
- Joan A. Edwards
- Anaerobic Fungi Network
- Sumit Singh Dagar
- Bioenergy Group, Agharkar Research Institute
- Andrew P. Foote
- Oklahoma State University, Department of Animal and Food Sciences
- Noha H. Youssef
- Oklahoma State University, Department of Microbiology and Molecular Genetics
- Mostafa S. Elshahed
- Oklahoma State University, Department of Microbiology and Molecular Genetics
- DOI
- https://doi.org/10.1038/s41467-023-39508-z
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
Abstract Despite their role in host nutrition, the anaerobic gut fungal (AGF) component of the herbivorous gut microbiome remains poorly characterized. Here, to examine global patterns and determinants of AGF diversity, we generate and analyze an amplicon dataset from 661 fecal samples from 34 mammalian species, 9 families, and 6 continents. We identify 56 novel genera, greatly expanding AGF diversity beyond current estimates (31 genera and candidate genera). Community structure analysis indicates that host phylogenetic affiliation, not domestication status and biogeography, shapes the community rather than. Fungal-host associations are stronger and more specific in hindgut fermenters than in foregut fermenters. Transcriptomics-enabled phylogenomic and molecular clock analyses of 52 strains from 14 genera indicate that most genera with preferences for hindgut hosts evolved earlier (44-58 Mya) than those with preferences for foregut hosts (22-32 Mya). Our results greatly expand the documented scope of AGF diversity and provide an ecologically and evolutionary-grounded model to explain the observed patterns of AGF diversity in extant animal hosts.
