Fosfomycin Resistance in Escherichia coli, Pennsylvania, USA

Abstract

Fosfomycin resistance in Escherichia coli is rare in the United States. An extended-spectrum β-lactamase–producing E. coli clinical strain identified in Pennsylvania, USA, showed high-level fosfomycin resistance caused by the fosA3 gene. The IncFII plasmid carrying this gene had a structure similar to those found in China, where fosfomycin resistance is commonly described.

Keywords

• fosfomycin resistance
• antimicrobial resistance
• fosA3 gene
• glutathione-S-transferase
• extended-spectrum β-lactamase
• ESBL