A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis

Penny J. Norsworthy; Andrew G. B. Thompson; Tze H. Mok; Fernando Guntoro; Luke C. Dabin; Akin Nihat; Ross W. Paterson; Jonathan M. Schott; John Collinge; Simon Mead; Emmanuelle A. Viré

doi:10.1038/s41467-020-17655-x

Nature Communications (Aug 2020)

A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis

Penny J. Norsworthy,
Andrew G. B. Thompson,
Tze H. Mok,
Fernando Guntoro,
Luke C. Dabin,
Akin Nihat,
Ross W. Paterson,
Jonathan M. Schott,
John Collinge,
Simon Mead,
Emmanuelle A. Viré

Affiliations

Penny J. Norsworthy: MRC Prion Unit at UCL, UCL Institute of Prion Diseases
Andrew G. B. Thompson: National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust
Tze H. Mok: National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust
Fernando Guntoro: MRC Prion Unit at UCL, UCL Institute of Prion Diseases
Luke C. Dabin: MRC Prion Unit at UCL, UCL Institute of Prion Diseases
Akin Nihat: National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust
Ross W. Paterson: Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square
Jonathan M. Schott: Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square
John Collinge: MRC Prion Unit at UCL, UCL Institute of Prion Diseases
Simon Mead: MRC Prion Unit at UCL, UCL Institute of Prion Diseases
Emmanuelle A. Viré: MRC Prion Unit at UCL, UCL Institute of Prion Diseases

DOI: https://doi.org/10.1038/s41467-020-17655-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive dementia. No clinical blood tests are available for diagnosis. The authors identified three miRNAs in whole-blood that are downregulated in sCJD patients, and discriminate sCJD from Alzheimer’s disease patients and healthy controls.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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