The dysfunctional Wnt pathway down-regulates MLH1/SET expression and promotes microsatellite instability and immunotherapy response in colorectal cancer

• Jiyan Wang,
• Tao He,
• Qingle Gao,
• Hongkai Chang,
• Xintong Dai,
• Juze Yang,
• Shuangping Liu,
• Shuai Zhang,
• Changliang Shan,
• Chunze Zhang

Affiliations

Jiyan Wang

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China

Tao He

Departments of Pathology, Characteristic Medical Center of The Chinese People's Armed Police Force, Tianjin 300162, China

Qingle Gao

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China

Hongkai Chang

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China

Xintong Dai

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China

Juze Yang

Department of Respiratory Medicine, Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China

Shuangping Liu

Department of Pathology, Medical School, Dalian University, Dalian, Liaoning 116622, China

Shuai Zhang

School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China

Changliang Shan

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China; Corresponding author.

Chunze Zhang

Department of Colorectal Surgery, Tianjin Union Medical Center, Nankai University, Tianjin 300121, China; Corresponding author.