The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection

Nadia Anikeeva; Maria Steblyanko; Leticia Kuri-Cervantes; Marcus Buggert; Michael R. Betts; Yuri Sykulev

doi:10.1038/s41467-022-34157-0

Nature Communications (Oct 2022)

The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection

Nadia Anikeeva,
Maria Steblyanko,
Leticia Kuri-Cervantes,
Marcus Buggert,
Michael R. Betts,
Yuri Sykulev

Affiliations

Nadia Anikeeva: Department of Microbiology and Immunology, Thomas Jefferson University
Maria Steblyanko: Department of Microbiology and Immunology, Thomas Jefferson University
Leticia Kuri-Cervantes: Department of Microbiology and Institute of Immunology, Perelman School of Medicine, University of Pennsylvania
Marcus Buggert: Department of Microbiology and Institute of Immunology, Perelman School of Medicine, University of Pennsylvania
Michael R. Betts: Department of Microbiology and Institute of Immunology, Perelman School of Medicine, University of Pennsylvania
Yuri Sykulev: Departments of Immunology and Medical Oncology, Thomas Jefferson University

DOI: https://doi.org/10.1038/s41467-022-34157-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

HIV infection over time is thought to result in premature aging and aberrant immune responses including the induction of immunological senescence. Here the authors show altered formation of immune synapses by naive CD8+ T cells and dysregulated synapse functioning at late differentiated stages in people living with HIV.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal