A Practical Standardized Fat Challenge for the Oral Fat Tolerance Test (OFTT) in Men and Women

Abstract

Abstract Postprandial lipemia (PPL) is associated with cardiovascular diseases, and it is assessed by the oral fat tolerance test (OFTT), which measures circulating triacylglycerol (TG). The objective is to propose an OFTT meal and to evaluate men’s and women’s perceptions, attitudes, sensory acceptability, and satiety. After overnight fasting, blood was collected (n=105), participants ingested the OFTT meal (75.4g lipids, 25.2g carbohydrates, and 10.8g protein/ 822.6 Kcal), and a new blood sample was collected 4h later. Fasting TG was 125.7±92.0 mg/dL (mean±SD) for men and 108.9±52.6 mg/dL for women. It increased by 97.7% and 86.7%, respectively, 4h after meal ingestion (P<0.0001), with no change in glucose. Participants felt satiated during the test. The meal was considered easy to eat and better tolerated by men. The median overall sensory acceptability was 7.0 [9-point hedonic scale]. The greatest fullness was seen in the first hour (magnitude satiety scale) and higher for women (P<0.01). The fatty meal proposed by the current study is adequate for the OFTT since it increased blood TG after 4h without hypoglycemia, it was easy to prepare, to eat, it kept participants satiated, and it displayed good perception, attitudes, and sensory acceptability.

Keywords

• postprandial lipemia
• oral fat tolerance test
• cardiovascular disease
• triacylglycerol