Research progress on pulmonary aspergillosis in patients with bronchiectasis

Abstract

Bronchiectasis is a chronic inflammatory disease of the airway in which one or more proximal bronchi （diameter greater than 2 mm） are irreversibly dilated caused by a variety of causes. Bronchiectasis is mainly caused by infection, and infection can induce bronchiectasis instead, which exert mutual effect. Bacteria have been proven as the major pathogens of infection by multiple studies. Aspergillus colonization is relatively rare in patients with bronchiectasis, whereas the pathogenesis remains elusive. Nevertheless, the incidence of pulmonary aspergillosis has been on the rise in recent years, especially in bronchiectasis patients complicated with infection. In addition, vitamin D level in bronchiectasis patients has been confirmed to be negatively correlated with the severity. However, relevant studies have seldom been reported. In this article, the relationship of bronchiectasis and pulmonary aspergillosis, their diagnosis and treatment were investigated, aiming to provide theoretical evidence for relevant research.

Keywords

• |bronchiectasis|infection|aspergillus|pulmonary aspergillosis|vitamin d