Circulating MicroRNAs in Gastrointestinal Cancer

Masahisa Ohtsuka; Kazuya Iwamoto; Atsushi Naito; Mitsunobu Imasato; Satoshi Hyuga; Yujiro Nakahara; Manabu Mikamori; Kenta Furukawa; Jeongho Moon; Tadafumi Asaoka; Kentaro Kishi; Awad Shamma; Hiroki Akamatsu; Tsunekazu Mizushima; Hirofumi Yamamoto

doi:10.3390/cancers13133348

Cancers (Jul 2021)

Circulating MicroRNAs in Gastrointestinal Cancer

Masahisa Ohtsuka,
Kazuya Iwamoto,
Atsushi Naito,
Mitsunobu Imasato,
Satoshi Hyuga,
Yujiro Nakahara,
Manabu Mikamori,
Kenta Furukawa,
Jeongho Moon,
Tadafumi Asaoka,
Kentaro Kishi,
Awad Shamma,
Hiroki Akamatsu,
Tsunekazu Mizushima,
Hirofumi Yamamoto

Affiliations

Masahisa Ohtsuka: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Kazuya Iwamoto: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Atsushi Naito: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Mitsunobu Imasato: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Satoshi Hyuga: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Yujiro Nakahara: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Manabu Mikamori: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Kenta Furukawa: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Jeongho Moon: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Tadafumi Asaoka: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Kentaro Kishi: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Awad Shamma: Department of Molecular Pathology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan
Hiroki Akamatsu: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Tsunekazu Mizushima: Department of Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka 543-0035, Japan
Hirofumi Yamamoto: Department of Molecular Pathology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan

DOI: https://doi.org/10.3390/cancers13133348
Journal volume & issue: Vol. 13, no. 13
p. 3348

Abstract

Read online

Gastrointestinal cancer (GIC) is a common disease and is considered to be the leading cause of cancer-related death worldwide; thus, new diagnostic and therapeutic strategies for GIC are urgently required. Noncoding RNAs (ncRNAs) are functional RNAs that are transcribed from the genome but do not encode proteins. MicroRNAs (miRNAs) are short ncRNAs that are reported to function as both oncogenes and tumor suppressors. Moreover, several miRNA-based drugs are currently proceeding to clinical trials for various diseases, including cancer. In recent years, the stability of circulating miRNAs in blood has been demonstrated. This is of interest because these miRNAs could be potential noninvasive biomarkers of cancer. In this review, we focus on circulating miRNAs associated with GIC and discuss their potential as novel biomarkers.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

About the journal

Abstract

Keywords