Frontiers in Oncology (Jun 2024)

Wnt signaling in gastric cancer: current progress and future prospects

  • Ruyue Han,
  • Jing Yang,
  • Yingying Zhu,
  • Runliang Gan

DOI
https://doi.org/10.3389/fonc.2024.1410513
Journal volume & issue
Vol. 14

Abstract

Read online

Levels of the Wnt pathway components are abnormally altered in gastric cancer cells, leading to malignant cell proliferation, invasion and metastasis, poor prognosis and chemoresistance. Therefore, it is important to understand the mechanism of Wnt signaling pathway in gastric cancer. We systematically reviewed the molecular mechanisms of the Wnt pathway in gastric cancer development; and summarize the progression and the challenges of research on molecular agents of the Wnt pathway.

Keywords