Nature Communications (Nov 2020)
Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
- Eran Mick,
- Jack Kamm,
- Angela Oliveira Pisco,
- Kalani Ratnasiri,
- Jennifer M. Babik,
- Gloria Castañeda,
- Joseph L. DeRisi,
- Angela M. Detweiler,
- Samantha L. Hao,
- Kirsten N. Kangelaris,
- G. Renuka Kumar,
- Lucy M. Li,
- Sabrina A. Mann,
- Norma Neff,
- Priya A. Prasad,
- Paula Hayakawa Serpa,
- Sachin J. Shah,
- Natasha Spottiswoode,
- Michelle Tan,
- Carolyn S. Calfee,
- Stephanie A. Christenson,
- Amy Kistler,
- Charles Langelier
Affiliations
- Eran Mick
- Division of Infectious Diseases, University of California
- Jack Kamm
- Chan Zuckerberg Biohub
- Angela Oliveira Pisco
- Chan Zuckerberg Biohub
- Kalani Ratnasiri
- Chan Zuckerberg Biohub
- Jennifer M. Babik
- Division of Infectious Diseases, University of California
- Gloria Castañeda
- Chan Zuckerberg Biohub
- Joseph L. DeRisi
- Chan Zuckerberg Biohub
- Angela M. Detweiler
- Chan Zuckerberg Biohub
- Samantha L. Hao
- Chan Zuckerberg Biohub
- Kirsten N. Kangelaris
- Division of Hospital Medicine, University of California
- G. Renuka Kumar
- Chan Zuckerberg Biohub
- Lucy M. Li
- Chan Zuckerberg Biohub
- Sabrina A. Mann
- Chan Zuckerberg Biohub
- Norma Neff
- Chan Zuckerberg Biohub
- Priya A. Prasad
- Division of Hospital Medicine, University of California
- Paula Hayakawa Serpa
- Division of Infectious Diseases, University of California
- Sachin J. Shah
- Division of Hospital Medicine, University of California
- Natasha Spottiswoode
- Division of Hospital Medicine, University of California
- Michelle Tan
- Chan Zuckerberg Biohub
- Carolyn S. Calfee
- Division of Pulmonary and Critical Care Medicine, University of California
- Stephanie A. Christenson
- Division of Pulmonary and Critical Care Medicine, University of California
- Amy Kistler
- Chan Zuckerberg Biohub
- Charles Langelier
- Division of Infectious Diseases, University of California
- DOI
- https://doi.org/10.1038/s41467-020-19587-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 7
Abstract
Here, the authors provide upper airway gene expression data from patients with COVID-19 and other viral and non-viral acute respiratory illnesses. They find attenuated activation of innate immune and pro-inflammatory pathways in COVID-19 as compared to other viral infections, which may contribute to its propensity for pre-symptomatic transmission.
