Genetic structure of the population and resistance to infections

Abstract

Numerous studies have shown that populations behave differently in the face of infections through contagion, evolution, severity and mortality. Both susceptibility and resistance to infections have a strong genetic conditioning. Genetic polymorphisms offer vulnerability/resistance to infectious agents being considered consequences of the evolutionary pressure induced by the co-evolution of germs and population. The study presents examples related to these statements, the most notorious being the mutation of CCR5 delta-32 against HIV infection. Based on the genetic data, explanations are proposed regarding the very different evolution of people in the face of SARS-CoV-2 infection and the chances of an occult immunization of the population.

Keywords

• genetic variability
• inflammatory response sensors
• factors that provide resistance to infections
• covid-19 immunity