Early Elevation of Thioredoxin-1 Serum Levels Predicts 28-Day Mortality in Patients with Sepsis

Abstract

Xing Li,* Hua Shen,* Tinghong Zhou, Xiaoyu Cao, Ying Chen, Yan Liang, Ting Lu, JiaFen He, ZhouLin Dou, ChuaiKai Liu, Yong Tang, Zeixang Zhu Department of Critical Care, Changsha of Traditional Chinese Medicine Hospital, Changsha, 410010, Hunan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zeixang Zhu; Yong TangDepartment of Critical Care, Changsha of Traditional Chinese Medicine Hospital, No. 22, Xingsha Road, Changsha, 410010, Hunan Province, People’s Republic of ChinaEmail [email protected]; [email protected]: Sepsis is the leading cause of death in critically ill patients, and the prevention of which requires precise outcome prediction and early intervention. We evaluated the prognostic prediction value of serum thioredoxin-1 (Trx-1) as an anti-inflammatory factor in patients with sepsis.Methods: As a prospective study, patients with sepsis admitted to the intensive care unit (ICU) of our hospital during 2020 were recruited. Medical history collection, sequential organ failure assessment (ΔSOFA), and laboratory tests were performed within 24 h of admission. Serum levels of Trx-1 and other inflammatory biomarkers were detected with samples dynamically collected before, during, and after septic shock. Patients were categorized as survivors and non-survivors according to survival status on day 28. Correlation between Trx-1 and other sepsis-associated parameters as well as the correlation of Trx-1 and other sepsis-associated parameters with 28-day mortality were evaluated. Prognostic factors were identified by Cox regression analyses.Results: A total of 187 patients were recruited. Serum Trx-1 level was positively correlated with inflammatory factors (interleukin-6, C-reactive protein, procalcitonin) and index of sepsis severity (ΔSOFA score, partial pressure of oxygen/fraction of inspired oxygen), all of which were significantly higher in non-survivors than survivors. While Trx-1 level at different timepoints and its evolution over time significantly differed between survivors and non-survivors, the initial Trx-1 level outperformed the other parameters in predicting 28-day survival. With 38.27 ng/mL as the cutoff value, serum Trx-1 predicted 28-day survival with optimal sensitivity and specificity.Conclusion: Early increases in serum levels of Trx-1 can predict 28-day mortality in sepsis patients in the ICU.Keywords: thioredoxin-1, prognosis, sepsis, mortality

Keywords

• thioredoxin-1
• prognosis
• sepsis
• mortality